Albuminomics is the study of the post-translational modifications (PTMs) of human serum albumin — the many chemically modified forms, or proteoforms, that a single albumin molecule can take — and their use as functional and structural biomarkers of liver disease, oxidative stress, and metabolic health.
Because albumin is synthesised exclusively by the liver and circulates for about three weeks, it acts as a long-lived molecular recorder: its modifications reflect weeks of metabolic and oxidative stress. Reading that record is what albuminomics does.
Start here
- What is albuminomics? — the concept, in one page
- History of the inventions — from exchangeable copper to the SEB test and isoform profiling
- Human serum albumin (HSA) — the molecule at the centre of it all
- About the author — Souleiman El Balkhi and the research programme
- Glossary — key terms defined
Explore by theme
- The modifications — Cysteinylation · Glycation · Oxidation · Carbonylation · Oxidative stress
- Methods — SEB test · Top-down proteomics · LC-MS · SRM
- Liver disease — DILI · Liver fibrosis · Acute liver failure
- Copper & Wilson disease — Exchangeable copper (REC) · Wilson disease
- Biomarker — HSA isoforms in liver disease
- Patents — Portfolio overview · SEB functional test · Isoform etiology profiling · Absolute quantification
- Key studies — ALBOM: multi-class fibrosis staging · SEB test · Absolute quantification method
Curated by Dr Souleiman El Balkhi — hospital practitioner and toxicologist at CHU de Limoges, and head of the biomarker axis at INSERM UMR1248 (P&T). Released under CC BY 4.0. · LinkedIn
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